Sarcosine is a prostate epigenetic modifier that elicits aberrant methylation patterns through the SAM e‐Dnmts axis
نویسندگان
چکیده
منابع مشابه
Aberrant DNA Methylation and Prostate Cancer
Prostate cancer (PCa) is the most prevalent cancer, a significant contributor to morbidity and a leading cause of cancer-related death in men in Western industrialized countries. In contrast to genetic changes that vary among individual cases, somatic epigenetic alterations are early and highly consistent events. Epigenetics encompasses several different phenomena, such as DNA methylation, hist...
متن کاملAberrant DNA methylation patterns in diabetic nephropathy
BACKGROUND The aim of this study was to evaluate whether global levels of DNA methylation status were associated with albuminuria and progression of diabetic nephropathy in a case-control study of 123 patients with type 2 diabetes- 53 patients with albuminuria and 70 patients without albuminuria. METHODS The 5-methyl cytosine content was assessed by reverse phase high pressure liquid chromato...
متن کاملDNA methylation patterns and epigenetic memory.
The character of a cell is defined by its constituent proteins, which are the result of specific patterns of gene expression. Crucial determinants of gene expression patterns are DNA-binding transcription factors that choose genes for transcriptional activation or repression by recognizing the sequence of DNA bases in their promoter regions. Interaction of these factors with their cognate seque...
متن کاملAberrant methylation patterns in cancer: a clinical view
Epigenetic mechanisms, such as DNA methylation, DNA hydroxymethylation, post-translational modifications (PTMs) of histone proteins affecting nucleosome remodelling, and regulation by small and large non-coding RNAs (ncRNAs) work in concert with cis and trans acting elements to drive appropriate gene expression. Advances in detection methods and development of dedicated platforms and methylatio...
متن کاملAberrant methylation patterns in colorectal cancer: a meta-analysis
Colorectal cancer is among the leading causes of cancer death worldwide. Despite numerous molecular characterizations of the phenomenon, the exact dynamics of its onset and progression remain elusive. Colorectal cancer onset has been characterized by changes in DNA methylation profiles, that, owing to the stability of their patterns, are promising candidates to shed light on the molecular event...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Oncology
سال: 2019
ISSN: 1574-7891,1878-0261
DOI: 10.1002/1878-0261.12439